Radiant Skin: Everything You Need to Know About PDRN Treatments (Plus PDGF Pairing!)

If you’re diving into the world of skincare and beauty treatments, you’ve probably heard about PDRN. But what if I told you that pairing it with PDGF could take your results next level? Here’s the scoop on how these two work together—and how an injection plan can totally revamp your skin!


What is PDRN (Polydeoxyribonucleotide)?

PDRN is a naturally occurring molecule extracted from salmon DNA (don’t worry, it’s super safe!). It helps with skin regeneration, wound healing, and collagen production. It’s like hitting the refresh button for your skin—hydrating, repairing, and firming it up.

What is PDGF (Platelet-Derived Growth Factor)?

PDGF is another powerhouse that stimulates cell growth and tissue repair. It’s often found in PRP (Platelet-Rich Plasma) treatments but can also be used in targeted serums and injectables. When combined with PDRN, it amplifies healing and collagen production, giving your skin even more of that youthful bounce.


Injection Treatment Plan: PDRN + PDGF

Want to know how the process works? Here’s a basic treatment plan outline for under-eye rejuvenation (but it can be used for the whole face too):

Treatment Plan:

  1. Session Frequency:

    • 3-4 sessions total

    • Spaced 2-3 weeks apart for best results

  2. Treatment Areas:

    • Under-eye area (for dark circles, fine lines, and puffiness)

    • Full face (optional for full glow-up)

  3. Procedure:

    • A micro-needle or fine needle injects a cocktail of PDRN + PDGF directly into the skin.

    • The combo works deep to stimulate collagen, repair tissue, and improve hydration.

    • Takes about 30-45 minutes, with mild redness or swelling that usually goes away within a day or two.

  4. Post-Treatment Care:

    • Hydrating serums, sunscreen, and gentle skincare for the first few days

    • Optional home care boosters like DMAE, Estriol, GHK-Cu, and Hyaluronic Acid to keep the glow going


Why Pair PDRN with PDGF?

Stronger together! PDRN and PDGF are like the ultimate skin-repair duo. Here’s what happens when you combine them:

  • Faster healing and collagen production

  • Deeper hydration and plumping

  • Stronger tissue regeneration (think fading scars and smoothing texture)

  • Brighter, more youthful skin overall

It’s a great combo for people dealing with aging skin, dark circles, fine lines, or acne scars.


Maintenance Plan:

After your initial series of treatments, you’ll want to maintain the results:

  • Every 3-4 months: One follow-up session to keep the collagen boost going

  • Home care products: Keep using hydrating and collagen-stimulating serums to support the treatment


Bonus: Add-Ons to Supercharge Results

Want even more dramatic results? Pair PDRN + PDGF injections with:

  • PDO Threads: For lifting and tightening

  • Sculptra: For deep collagen stimulation and volume restoration

  • Microneedling: For even better absorption of the PDRN/PDGF cocktail

Beauty Refined

Talk to Us!

We are dedicated to helping you achieve your wellness and aesthetic goals. Whether you have questions about our services, need assistance with booking an appointment, or want to learn more about our treatments, we’re here to help.

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Amber Tomse, MSN, APRN, FNP-C, combines medical expertise with personalized care to deliver natural, refreshed results in skincare and wellness. Dedicated to safety and excellence, she helps patients feel confident inside and out.

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